Icodextrin CAS 337376-15-5 comes in two sizes: pharmaceutical grade (for peritoneal dialysis and ointments) and cosmetics (for skin care products such as masks).

Peritoneal dialysis refers to the use of the patient's own peritoneum as a dialysis membrane to filter blood in the abdominal cavity to remove toxins, metabolic wastes and excess water from the body. Peritoneal dialysis is one of the main methods of renal replacement therapy in patients with end-stage renal disease, because it is safe, effective, simple to operate, and can be treated at home, and has been widely used. At present, peritoneal dialysis uses glucose as a penetrant, but glucose is easily absorbed by the peritoneum, which can cause a series of problems. Icodextrin peritoneal dialysate compensates for the limitations of traditional glucose peritoneal dialysis in the past and will benefit patients with end-stage renal disease.

Icodextrin peritoneal dialysate uses macromolecular dextran as a penetrant, which is not easy to be absorbed by the peritoneum, and can achieve long-term stable ultrafiltration, which is an innovative drug suitable for the prevention and treatment of fluid overload in peritoneal dialysis patients. In addition to the good ultrafiltration effect, the peritoneal dialysate of icodextrin can achieve long-term stable ultrafiltration, and its abdominal retention time can reach 8 to 16 hours, which can effectively reduce the number of peritoneal dialysis per day and improve the quality of life of patients.

Specifications of Icodextrin/Extraneal CAS 337376-15-5

Item Specification

Appearance White to beige powder

Assay 95.0%min

Specific rotation (20%C,) +190~ +200

Loss on Drying (120°C+2°C, %) ≤7.0

Residue on ignition (%) ≤0.2

Icodextrin is a type of carbohydrate polymer that is used in medical applications, primarily in peritoneal dialysis solutions. Peritoneal dialysis is a procedure used to remove waste products and excess fluid from the blood when the kidneys are no longer functioning properly.

Icodextrin serves as an osmotic agent in peritoneal dialysis solutions, helping to draw waste products and excess fluid from the blood into the peritoneal cavity, where it can be removed. It is particularly useful because it has a longer dwell time in the peritoneal cavity compared to other osmotic agents like glucose, allowing for more effective dialysis over longer periods of time.

Additionally, icodextrin has also been investigated for its potential use in other medical applications, such as in drug delivery systems and as a stabilizer in pharmaceutical formulations.

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