As we know the COVID-19 pandemic is a scientific, medical, and social challenge. The syndrome coronavirus 2 (SARS-CoV-2 detection) can rapidly develop, causing severe and deadly complications. The sars rapid test is an important method of dealing with the pandemic. The identification of effective laboratory biomarkers able to classify patients based on their risk is imperative in being able to guarantee prompt treatment. Analysis of recently published studies suggests that systemic vasculitis and cytokinin-mediated coagulation disorders are major factors in multiple organ failure in patients with severe COVID-19 complications.