1.What Is Cagrilintide?

Cagrilintide powder is a long-acting amylin analogue under development for the treatment of obesity and type 2 diabetes, now being developed in combination with the GLP-1 agonist semaglutide as a new drug CagriSema to achieve sustained weight loss in persons with overweight and obesity. Cagrilintide powder induces satiety by releasing amylin and delays gastric emptying to achieve weight loss.

2.What Is CagriSema(Cagrilintide and Semaglutide)?

Cagrilintide/semaglutide, marketed as CagriSema, is a combination of cagrilintide, a dual amylin and calcitonin receptor agonist, and semaglutide, a GLP-1 agonist. It is being tested in type 2 diabetes and obesity. These separate, but related mechanisms of action of an amylin-analog and a GLP-1 receptor agonist appear to have an additive effect on appetite reduction. The combination of cagrilintide and semaglutide has shown good tolerability in clinical trials, has a weight loss effect, and can achieve sustained weight management.

3.How Does Cagrilintide Work?

Cagrilintide powder works as a long-acting acylated amylin analogue that has agonistic effects on amylin and calcitonin receptors. Amylin is a glucoregulatory pancreatic hormone. When cagrilintide injection, more amylin is produced, which is involved in delaying gastric emptying and inducing a feeling of fullness through the homeostatic and hedonic areas of the brain. It can also inhibit the release of glucagon after a meal, thereby achieving weight loss.

4.Cagrilintide Benefits

①Treatment of type 2 diabetes

Cagrilintide powder has health benefits in people in persons with overweight and obesity, reducing the risk of type 2 diabetes and cardiometabolic diseases.

②Weight loss

Cagrilintide powder is a new investigational drug that exhibited some promising results in a recently completed phase II clinical trial for treatment of obesity .It mainly acts on amylin to delay gastric emptying, increase satiety, and achieve the purpose of weight loss.

③Regulate hedonic emotion

It is important that cagrilintide powder acts not only to induce satiety, but also seems to regulate hedonic (emotional/wanting/liking) aspects of food intake. Many people with elevated weight struggle with cravings and the irresistible pleasure of food, and describe a relief from these draws when on medication that dampens these feelings.