I.Raw PRL-8-53 powder basic Characters:

Name: PRL-8-53 powder

CAS: 51352-87-5

Molecular Formula: C18H22ClNO2

Molecular Weight: 319.82578

Melt Point: 149-152℃

Storage Temp: Refrigerator

Color: White or off-white powder

II. Raw PRL-8-53 powder in enhancing brain function and an extra boost

1. Names:

Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate

2. Raw PRL-8-53 powder Usage:

The only human study on PRL-8-53 powder was based on the ingestion of a single 5 mg dose. There is no data on the effectiveness or potential toxicity of any other dosage in humans.

3.Warning on Raw PRL-8-53 powder:

According to the evidence with rats, PRL-8-53 powder seems to be a dopamine agonist. This means that it can improve dopamine receptors and is often used in Parkinson’s patients. For people who do not need this feature, it could be an unwanted sideeffect of PRL-8-53 raw powder.

The toxicity studies in rats show a relatively high threshold with LD50 rates, but obviously further evidence is needed. Also, it seems a potential side effect of PRL-8-53 powder is a reduction in motor activity within the brain.

4.Further instructions:

PRL-8-53 powder’s Mechanism Of Action

The mechanism of action for this nootropic is currently unknown but may, in part, lie with cholinergic mechanisms. Dr Hansl, the creator of the compound discusses in the Phi Delta Kappan journal that PRL-8-53 powder enhances brain’s the response to acetylcholine, and the compound is not a stimulant. The patent for PRL-8-53 raw powder mentions cholinergic mechanisms.

An animal test involving rodents showed 4mg/KG increased apomorphine (dopamine agonist) increased compulsive gnawing in rats, suggesting that PRL-8-53 raw powder to some extent is a dopamine agonist . The same study noted an improvement in conditioned avoidance learning. This nootropic does not enhance amphetamine’s actions in rats and doesn’t appear inhibit MAO activity.The single study in humans briefly mentions that PRL-8-53 raw powder potentiates dopamine release and causes partial inhibition of serotonin.

Benefits of Raw PRL-8-53 powder:

(1)Memory

The single published study for PRL-8-53 powder shows a slight improvement of word acquisition during a memorization task. Participants were given 5mg of PRL-8-53 powder 2 hours prior to testing and then were then asked to listen to a recording of 12 words in a particular sequence and recite them at future time points (shortly after testing, a day after and 4 days after). Minor benefits were found for immediate acquisition, but an over 80% improvement was noted for people tested later on who had initially scored poorly for the test (6/12 words correctly or below).

(2)Unpublished (Possible) Benefits – Geometric Pattern Exercise

Interestingly, the compound creator also discusses other trials which appear to be unavailable or unpublished. In a Journal published in 1978, Dr Hansl mentions that PRL-8-53 powder statistically improved scores in a geometric pattern cognitive exercise. Participants were shown a series of geometric patterns and ask to draw them from memory, a statistical improvement was noted.

(3)Mental Arithmetic Exercise

In the same article, Dr Hansl mentions a number based cognitive exercise where participants had to subtract 7, add 1, subtract 7, add 2 and so on until a “goal” number was reached. Shorter times to the “goal” number were noted in the PRL-8-53 raw powder group.

(4)Verbal Fluency Test

Dr Hansl discusses a test where subjects were asked to form words from a series of letters and dots. For example “U.R.” had to be turned into any word by adding letters at the start and end of the word, while replacing the dots with a letter. “U.R.” could be “current” for example. A statistically significant improvement was found in participants who had taken the drug.

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