CytoLinX® BR 50-2000 L single-use mobius bioreactor is developed based on DCS architecture, and its underlying logic is built by Siemens PCS 7, so as to cover the automatic control requirements from R&D to production, from a single unit to the whole upstream plant, and its automatic control logic conforms to ISA 88 control standards. The disposable bioreactor for cell culture can cover 50, 200, 500, 1000, 2000 L scale, its software design in accordance with GMP and 21 CFR Part 11 requirements. At the same time, in order to facilitate the use of users, CytoLinX® BR software interface design is minimal, all functions at a glance, and can greatly meet the needs of customers. The automatic control system can meet the functions of real-time data acquisition and recording, PID automatic control, online monitoring, multi-parameter cascade control, and has stable pH, DO, temperature control performance.

For more efficient mixing, BioLink has introduced a new bottom dial design that can maintain a high linear KLa. And provide microbubble, medium bubble, large bubble and a variety of combinations of consumable solutions, to meet the needs of a variety of cells tricky culture.

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More About CytoLinX® BR 50-2000 L Single-Use Bioreactor

The supporting single-use consumables can be selected according to the needs of customers, such as micro-bubble, medium-bubble, big-bubble and other ventilation combinations. The perfusion bioreactor has a stable linear kLa, and the cultivation effect is comparable to most reactors on the market.

Functions of CytoLinX® BR 50-2000 L Single-Use Bioreactor

CytoLinX® BR 50-2000 L Single-use Stirred Tank Bioreactor comes standard with working volumes of 50 L, 200 L, 500 L, 1000 L, and 2000 L. Including a vessel, a controller and a temperature control unit (TCU), it is used for culturing mammalian cells, in-sect cells, and other low shear-rate needed cells.

CytoLinX® BR Controller — The Controller of Single-Use Bioreactors

CytoLinX® BR controller consists of control hardware and underlying hardware modules. CytoLinX® BR's controller is built with SIEMENS PCS 7 which meets the automation requirements from research to production, as well as from single system to enterprise-wide solution. The software fits lSA 88 control standard and 21 CFR Part 11.

Hardware control units are all built with international famous brands to ensure robust and reliable performance. Also, a choice of PAT tools can be configured flexibly to meet different customer needs and applications.

One CytoLinX® BR controller can control different types of BioLink single-use Bioreactors vessels at the same time. We can also use CytoLinX® BR controller as an integrated control center to realize upstream centralized control by controlling several single-use Bioreactors vessels simultaneously.

CytoLinX® BR Vessel — The Vessel of Single-Use Bioreactors

CytoLinX® BR Vessel operates with bottom-drive agitators. It has a patented sparge design that supports flexible combinations of micro, medium and macro sparge sizes, helping to optimize the culture process, enhance the cell density, and maintain cell viability.

For the operation of CytoLinX® BR, two types (air-cooled and water-cooled) of temperature control units (TCU) are available to meet customers' specific needs in different applications.

Features of CytoLinX® BR 50-2000 L Single-Use Bioreactor

A single controller supports the control of multiple vessels by plugging and unplugging, which contributes to significant cost reduction.

Reliable PCS 7 system that meets ISA 88 standard, applicable for whole-plant control.

The software is designed with user-friendly interface in compliance with 21 CFR Part 11.

Flexible configurations, partly customizable upon customer requirements.