I.Sunifiram(DM235) powder basic Characters:

Name: Sunifiram(DM235) powder

CAS: 314728-85-3

Molecular Formula: C15H13F2NO2S

Molecular Weight: 309.33

Melt Point: 57-58 °C

Storage Temp: Store at room temperature or cooler

Color: White or off-white powder

II. Sunifiram(DM235) powder in brain boost usage

1. Names:

Sunifiram powder,DM235 powder is with trade name as BisfluoroModafinil, Flmodafinil.

2.DM235 powder Usage:

DM235 powder is a novel, highly potent nootropic and AMPAkine-like compound with cognition-enhancing effects in animal models.

Sunifiram powder is a piperazine which has some structural similarities to piracetam. Piracetam was developed for neurodegenerative disorders like Alzheimer’s disease, and Sunifiram powder is known to enhance cognitive function in some behavioral experiments. In receptor binding studies, Sunifiram raw powder does not show affinity for most neurotransmitter receptors or channels (no affinity at 1μM for serotoninergic, dopaminergic, muscarinic, nicotinic, adrenergic, glutamatergic, histaminergic, opioid, or GABAergic receptors), yet promotes the release of acetylcholine from rat cerebral cortex, likely through positive modulation of AMPA receptor response.

Sunifiram powder prevents amnesia induced by scopolamine, after i.p. and p.o. administration, in the mouse passive avoidance test with a minimal effective dose of 0.01 mg/kg p.o. The antiamnesic effect of Sunifiram powder is comparable to that exerted by well known nootropic drugs such as piracetam (30 mg/kg i.p.), aniracetam (100 mg/kg p.o.) and rolipram (30 mg/kg p.o.), but with a potency 1,000 – 10,000 times higher.

3.Warning on DM235 powder side effects

Sunifiram powder (DM-235) is a piperazine derived research chemical which has anti-amnesiac effects in animal studies with significantly higher potency than piracetam. Sunifiram raw powder is a molecular simplification of unifiram. Based on in vitro and animal studies, it appears that Sunifiram powder acts via AMPA-receptor activation.

Sunifiram raw powder operates by activating AMPA receptors; that is, the receptors that are responsible for the mediation of synaptic transmission in the central nervous system. Its mechanics also increases phosphorylation of AMPAR and NMDAR through protein kinase activation, which in turn enhances long-term potentiation – that is, an enhancement in signal transmission between two neurons resulting from simultaneous stimulation.

The kinase activation that is influenced by Sunifiram powder also improves cognitive defects. Additionally, Sunifiram raw powder works in the cerebral cortex of animal test subjects by assisting in the release of acetylcholine, the organic molecule that acts as a neurotransmitter in a host of various organisms. These operational mechanisms enable Sunifiram powder to exert anti-amnesiac properties.

4.Further instructions:

Sunifiram powder is also able to prevent the amnesia induced by the nicotinic antagonist mecamylamine, the GABAB agonist baclofen, the α2 agonist clonidine and the AMPA receptor antagonist NBQX in the passive avoidance test.

In the rat Morris water maze test, the administration of scopolamine inhibits the reduction of escape latency in both acquisition and retention retraining test. Sunifiram raw powder, administered 20 min before each daily acquisition training, is able to prevent scopolamine-induced memory impairment at 0.1 mg/kg i.p.

Sunifiram powder produces maximal antiamnesic and procognitive effects without any visible modification in gross behavior of mice or rats, and at 0.1 mg/kg i.p., Sunifiram powder reduces the duration of hypnosis induced by pentobarbital in mice without modifying the induction time of hypnosis. Moreover, mice treated with Sunifiram raw powder retain motor coordination in the rotarod test.

Email: aas14@aasraw.com

www.aasraw.com